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Correlations between Hepatitis B DNA and Serum Markers
Author(s): 
Pages: 237-238
Year: Issue:  3
Journal: OCCUPATION AND HEALTH

Keyword:  HBV血清学标志物HBV-DNA;
Abstract: 目的 研究HBV血清学标志物和HBV-DNA两者之间的相关性,为确定乙肝检测项目提供科学依据.方法 对福州市整群抽样调查的健康人群用酶联免疫吸附试验(ELISA)法检测HBV血清学标志物,采用核酸扩增(PCR)荧光定量检测法检测HBV-DNA,并采用SPSS 13.0软件进行统计分析.结果 498例HBsAg阳性血清中,HBV-DNA阳性327例,阳性率为65.66%;乙肝大三阳HBV-DNA阳性率为90.35%,小三阳HBV-DNA阳性率为59.07%,两者差异有统计学意义(P<0.01);HBeAg阳性标本中HBV-DNA阳性率为90.00%,HBeAg阴性标本中HBV-DNA阳性率为57.94%,两者差异有统计学意义(P<0.01).结论 HBV血清学标志物和HBV-DNA二者之间互有联系但又有所不同,不能只以HBeAg的检测结果作为判断HBV传染性和复制的指标,而应选择检测HBV-DNA作为补充.
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