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Influence of Electroacupuncture of "Baihui"(GV 20) and "Sanyinjiao"(SP 6) on Hippocampal 5-HT and AChE Immuno-activity in Chronic Depression Rats
Pages: 16-20
Year: Issue:  1
Journal: Acupuncture Research

Keyword:  DepressionElectroacupunctureHippocampus5-HTAChE;
Abstract: Objective To investigate the influence of electroacupuncture(EA) on 5-serotonin(5-HT) and acetyl cholinesterase(AChE) activities in hippocampus tissue in chronic stressed-induced depression rats.Methods Thirty-two Wistar rats were randomized into normal control group(n=10),model group(n=11) and EA group(n=11).Chronic depression model was established by lonely raising,and chronic unpredictable mild stress for 21 days.EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Sanyinjiao"(SP 6) for 20 minutes,once daily for 14 days.5-HT and AChE expression of hippocampal CA 4 region was detected by using immunohistochemistry,and their integrated optical density(IOD)values were determined by using image analysis system.Results Compared with normal control group,IOD values of 5-HT and AChE immuno-reaction(IR) positive neurons in hippocampal CA 4 region of model group decreased significantly(P<0.05).In comparison with model group,the IOD values of 5-HT and AChE IR positive neurons of CA 4 region in EA group increased significantly(P<0.05).No significant differences were found between EA and normal control groups in IOD values of both 5-HT and AChE IR positive neurons.Conclusion EA can upregulate 5-HT and AChE expression in hippocampal CA 4 region in depression rats,which may contribute to its effect in relieving depression.
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