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Epigenetic activation of IGF2 during cellular senescence
Author(s): 
Pages: 1-3,8
Year: Issue:  1
Journal: Journal of Hygiene Research

Keyword:  cellular senescenceinsulin-like growth factor 2methylationacetylationinsulin;
Abstract: 目的 观察体外培养人胚肺成纤维细胞复制性衰老过程中及过氧化氢诱导早衰持续阶段胰岛素样生长因子2(IGF2)表观遗传学修饰.方法 荧光定量PCR检测 IGF2的mRNA表达,甲基化特异PCR检测其启动子区甲基化改变,染色质免疫沉淀结合定量PCR检测组蛋白修饰,包括组蛋白H3、H4乙酰化,H3(Lys4)及H4(Lya20)甲基化修饰.结果 细胞复制性衰老过程中,中年细胞组及复制性衰老细胞组IGF2的...
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