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COMBINED EFFECTS OF ETHANOL, TOLUENE, BENZENE ON HEMATOPOIESIS OF BONE MARROW IN BALB/C MICE
Author(s): 
Pages: 59-61
Year: Issue:  2
Journal: OCCUPATIONAL HEALTH AND EMERGENCY RESCUE

Keyword:  乙醇骨髓造血干细胞微环境联合毒作用;
Abstract: 目的探讨乙醇、甲苯、苯对骨髓造血干细胞和造血微环境的联合毒作用.方法乙醇、甲苯、苯对雌性BALB/C小鼠染毒27周,应用脾集落技术测定其多向造血干细胞和应用整体灌注固定原位电镜观察其骨髓造血微环境.结果在染毒2~4个月时40mg/m3苯合并自由饮用10%乙醇组较单纯同等剂量苯染毒对骨髓多向造血干细胞形成有促进作用,且FCM测定示其骨髓细胞合成期比例显著增加,并出现异倍体峰,提示乙醇增强了苯的诱癌作用;且对造血微环境的损伤作用明显增强,如晚幼粒细胞内含有髓样小体,并出现形态各异的特殊颗粒,针状包涵体,血窦窦壁不完整.结论高剂量苯暴露减低骨髓造血干细胞形成和损伤造血微环境.乙醇加强苯的毒性,而甲苯具一定保护作用.
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