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ANALGESIC EFFECTS OF LEVO-TETRAHYDROPALMATINE COMBINED WITH URB597 OR URB602 RESPECTIVELY IN A RAT MODEL OF CHRONIC CONSTRICTION INJURY PAIN
Author(s): 
Pages: 735-738
Year: Issue:  12
Journal: Chinese Journal of Pain Medicine

Keyword:  延胡索乙素坐骨神经慢性压迫损伤URB597URB602;
Abstract: 目的:观察延胡索乙素(levo-tetrahydropalmatine,L-THP)分别与脂肪酸酰胺水解酶(fatty acid amide hydrolase,FAAH)、单酰甘油脂肪酶(monoacylglycerol lipase,MAGL)特异性抑制剂URB597、URB602分别联合应用对坐骨神经慢性压迫损伤(chronic constriction injury,CCI)所致大鼠神经病理性疼痛的影响.方法:成年健康雄性Wistar大鼠30只,体重180~220 g,随机分为5组(n=6):假手术组、CCI组、延胡索乙素CCI组、延胡索乙素URB597 CCI组、延胡索乙素URB602 CCI组.假手术组仅暴露坐骨神经但不结扎,其余组均暴露并结扎坐骨神经.术毕即刻,延胡索乙素CCI组、延胡索乙素URB597 CCI组和延胡索乙素URB602 CCI组腹腔注射延胡索乙素40 mg/(kg·d),连续14 d;假手术组和CCI组给予等量生理盐水.术后11d开始,延胡索乙素URB597 CCI组、延胡索乙素URB602 CCI组手术切口局部分别注射URB597、URB602 0.3 mg/(kg·d),连续4d,假手术组、CCI组、延胡索乙素CCI组注射等量生理盐水.于术前1d、术后3d、7d、11d、12d、13d、14d测试各组大鼠机械痛阈(mechanical withdrawal threshold,MWT)和热痛阈(thermal withdrawal latency,TWL).结果:与术前和假手术组比较,CCI组、延胡索乙素CCI组、延胡索乙素URB597 CCI组和延胡索乙素URB602 CCI组大鼠,术后3d开始各时间点机械痛阈和热痛阈显著降低(P<0.05);与CCI组比较,延胡索乙素CCI组、延胡索乙素URB597 CCI组和延胡索乙素URB602 CCI组大鼠术后3d、7d、11d、12d、13d、14d机械痛阈和热痛阈显著提高(P<0.05);与延胡索乙素CCI组比较,延胡索乙素URB597 CCI组、延胡索乙素URB602 CCI组大鼠,术后11d、12d、13d、14 d机械痛阈和热痛阈明显提高(P<0.05);与延胡索乙素URB597 CCI组比较,延胡索乙素URB602 CCI组大鼠各时间点机械痛阈和热痛阈无显著性差异(P>0.05).结论:在CCI大鼠模型中,延胡索乙素可以产生良好的镇痛作用,当分别与URB597、URB602合用时可以增强其镇痛作用.
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