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han fang ji jia su dui xi fei da shu fei nei lin zhi cheng fen de ying xiang
Author(s): 
Pages: 5-8
Year: Issue:  2
Journal: Journal of Hygiene Research

Keyword:  肺表面活性物质磷脂成分构成比矽肺汉防己甲素大鼠肺组织卵磷脂正常大鼠肌醇磷脂肺内;
Abstract: 本文分析了正常鼠、矽肺鼠及汉防已甲素治疗的矽肺鼠肺组织及肺表面活性物质中主要磷脂成分的含量及磷脂构成比。结果表明矽肺鼠较正常鼠肺组织中主要磷脂成分含量有增高,汉甲治疗鼠较矽肺鼠主要磷脂成分量降低并且在肺组织中磷脂的构成比发生了改变,其原因主要是由于肺表面活性物质量的增减及磷脂构成比的改变所致。提出肺表面活性物质中饱和卵脂的含量可作为评价粉尘对肺脏的毒性及药物疗效观察的指标,而汉防已甲素是降低肺内脂类抑制肺纤维化进展较理想的药物。
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