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han fang ji jia su yu pvno( ke xi ping ) he yong dui da shu xi fei de liao xiao yan jiu
Author(s): 
Pages: 1-6
Year: Issue:  2
Journal: Journal of Hygiene Research

Keyword:  治疗效果汉防己甲素巨噬细胞治疗后肾组织合并用药实验性矽肺大鼠纤维化克矽平;
Abstract: 1.本文采用不同剂量的汉防己甲素和PVNO合并用药治疗大鼠实验性矽肺,并与汉防己甲素、PVNO单一用药组进行疗效对比。实验分十组,结果表明汉防己甲素与PVNO合用可以提高药物对矽肺的治疗效果。剂量为62.5mg/kg·周的汉防己甲素与10mg/kg·周的PVNO合用组的治疗效果与125mg/kg·周的汉防己甲素与10mg/kg·周的PVNO合用组的疗效基本相似,且无肝、肾的毒作用。因此,建议汉防己甲素与PVNO合用的剂量为62.5mg/kg·周。2.低剂量的PVNO(总量42mg/只)与汉防己甲素合用时一次总量皮下注射表现有明显抑制大鼠矽肺的发展。该剂量按每周10mg/kg与汉防己甲素合用分次皮下给药未见疗效。3.简单讨论了汉防己甲素和PVNO治疗矽肺的药理作用。
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