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EFFECT OF PUERARIN ON THE LEVEL OF ADRENALINE IN PLASMA OF RATS INTOXICATED BY DELTAMETHRIN
Author(s): 
Pages: 116-117
Year: Issue:  3
Journal: OCCUPATIONAL HEALTH AND EMERGENCY RESCUE

Keyword:  普乐林溴氰菊酯肾上腺素;
Abstract: 目的探讨普乐林对溴氰菊酯中毒大鼠心血管毒性拮抗作用的机制.方法雄性大鼠一次性腹腔注射溴氰菊酯后,用高压液相色谱测定血浆中肾上腺素的水平,并观察普乐林对上述改变的影响.结果溴氰菊酯可引起大鼠血浆中肾上腺素水平持续升高,90min时达到平台期.12.5mg/kg溴氰菊酯对大鼠血浆中肾上腺素水平的改变不明显(P>0.05);25或50mg/kg溴氰菊酯可使大鼠血浆中肾上腺素水平明显升高(P<0.05).普乐林能明显地缓解50mg/kg溴氰菊酯对大鼠肾上腺素的释放作用.结论普乐林对溴氰菊酯心血管毒性的拮抗作用可能涉及肾上腺素释放的抑制.
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