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sha chong shuang zai dong wu ti nei de dai xie yan jiu si sha chong shuang de qi xiang se pu fa ce ding ji qi zai tu ti nei de du wu dai xie dong li xue yan jiu
Pages: 18-22+55
Year: Issue:  5
Journal: Journal of Hygiene Research

Keyword:  Shachongshuangnereistoxingas liquid chromatographic methodtoxicokinetics;
Abstract: A specific and sensitive method of analysis for Shachongshuang (Ⅰ)and Nereistoxin (Ⅱ) in plasma by GC-FPD was established. The detection limit of (Ⅱ) was 0.5ng. The recoveries of(Ⅰ)and(Ⅱfrom plasma were more than 90%. When (Ⅰ) was administered by iv.,(Ⅱ)might be detected after 30". The toxicokinetics of (Ⅰ) and (Ⅱ) in rabbits fitted the open two compartment model. After iv. injection of 2mg/kg of(Ⅰ)the toxicokinetic parameters of (Ⅰ) and (Ⅰ) were as follows respectively:α=0.683, 0.748 min~(-1).;β= 0.077, 0.052min~(-1).; t1/2α= 1.01,0.93min.; t1/2β=9.02, 13.4lmin.;K_10=0.243,0.216min~(-1).; K_(12)=0.301. 0.405min~(-1).; K_(21)= 0.216, 0.l79min~(-1).;Vc=112.20, 210.00ml/kg; Vd=353.97, 874.50ml/kg; Auc=73.37, 18.47μgmin. ml~(-1); Cl= 27.26,45. 36ml kg~(-1).min~(-1). The toxicokinetic characteristics remained unchanged when the dose Was doubled. There was no (Ⅰ) and (Ⅱ)in plasma sample after intragastric adiministration.
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