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xi de ren ti zui da an quan she ru liang yan jiu liu xi de zui gao jie xian she ru liang he zui da an quan she ru liang
Author(s): 
Pages: 25-29+56
Year: Issue:  5
Journal: Journal of Hygiene Research

Keyword:  selenosismaximum safe margin of daily Se intakemaximum daily safe intake of Se;
Abstract: No cases of selenosis had been diagnosed among 349 adult inhabitants as the blood-Se level was below 1.02μg/ml. Furthermore, the minimum blood-Se level to cause persistent finger-nail symptoms among 5 susceptible cases was 1.054μg/ml ( daily Se intake 910μg). Biochemical parameters indicate that cases of delay blood prothrombin time distinctly increases as blood-Se level increases to beyond 1μg/ml (daily Se intake 850μg). In addition ,plasma-Se to erythrocyte-Se ratio decreases to around 1/3 to 1/4 of that in low blood-Se state as blood-Se level increases to approach 0.9μg/ml(daily Se intake 750μg).Above results indicate the maximum safe margin of daily Se intake should be at a range of 750-850μg. When individual variation is taken into consideration, a maximum daily safe intake of Se is 400μg as a safety factor of 2.0 is applied. For seleniferous area,however, a safety factor 1.3 is applied as other influence factors such as adaptation and environmental antagonistic elements are considered, and the maximum daily safe intake is around 550μg.
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