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xi ru ben chan sheng zi you ji dui wai zhou xue du zuo yong de shi yan yan jiu
Author(s): 
Pages: 14-16
Year: Issue:  S1
Journal: Occupational Health and Emergency Rescue

Keyword:  自由基大鼠外周血脂质过氧化;
Abstract: 在本研究中,大鼠吸入三个不同浓度(6.3ppm,71.8ppm,459.5ppm)苯30天以及吸入71.8ppm不同时间(10,20,30天)后,测定了反应血中自由基活性的指标如白细胞过氧化脂质(LPO),血浆过氧化脂质、红细胞超氧化物歧化酶(SOD)、红细胞谷胱甘肽(GSH)。结果显示各染毒组在30天后白细胞LPO均较对照组明显升高,而白细胞显著减少仅发生在中、高剂量组。大鼠吸入71.8ppm20天和30天后白细胞LPO异常升高,白细胞数明显下降。红细胞SOD、GSH以及血浆LPO在所有染毒组均未见异常变化。结果提示大鼠吸入苯后外周血白细胞的下降可能与其膜脂质过氧化有关,白细胞过氧化脂质升高比白细胞减少更为敏感。
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