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la mi fu ding dui fei jie he he bing man xing yi xing gan yan huan zhe de liao xiao guan cha
Author(s): 
Pages: 509-510
Year: Issue:  4
Journal: Occupation and Health

Keyword:  肺结核慢性乙型肝炎拉米夫定抗病毒抗结核;
Abstract: 目的观察拉米夫定在肺结核合并慢性乙型肝炎(乙肝)患者治疗中控制肝脏损伤和抑制乙肝病毒(HBV)复制的作用。方法患者随机分为2组,对照组给予2HRZE/4HR+维生素C+护肝片,观察组给予2HRZE/4HR+拉米夫定+维生素C+护肝片,以评价患者治疗前后肝功能及HBV-DNA水平的变化。结果治疗过程中观察组肝功能损害发生率为12.8%,而对照组为48.7%(P<0.05);治疗结束时观察组HBV-DNA水平为(4.1±0.2)log copies/ml,而对照组为(8.7±0.3)log copies/ml(P<0.05);停药随访期间,2组间肝功能损害和HBV-DNA水平间的差异无统计学意义(P>0.05)。结论拉米夫定能有效抑制HBV的复制,减少肝功能损害的发生率,从而有利于肺结核合并慢性乙肝患者的抗结核治疗。
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