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Study on the anti-bacterial function of berberine in vivo of mice
Author(s): 
Pages: 684-686
Year: Issue:  5
Journal: Journal of Southwest University for Nationalities(Natrual Science Edition)

Keyword:  小檗碱小鼠体内抑菌;
Abstract: 目的:研究小檗碱对抑制小鼠体内沙门氏菌感染的效果.方法:通过将60只SPF级昆明小鼠随机等分为4组,每组15只.按体重计算1-3组小鼠分别按照低剂量(0.01 g/kg)、中剂量(0.02g/kg)、高剂量(0.03g/kg)灌胃小檗碱0.2 mL,第4组为空白对照组灌胃生理盐水,给药七天后皮下注射沙门氏菌(2.3× 108CFU)建立人工感染小鼠模型,并观察小鼠临床表现与死亡情况.结果:各剂量药物组对抑制小鼠体内沙门氏菌感染效果明显,其中高剂量组使小鼠死亡率下降60%左右.各药物组均显著延长感染小鼠的存活时间,其中高、中剂量组与空白对照组差异极显著(P<0.01).结论:此研究证明小檗碱对革兰氏阴菌感染小鼠体有很好的抑菌效果,并具有一定量效关系.
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