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guo wai zi liao zuo zuo
Pages: 45-48
Year: Issue:  4
Journal: Occupational Health and Emergency Rescue

Keyword:  显性致死试验遗传毒性国外资料胚胎数胚胎死亡率效应关系雌鼠化学诱变接触组铅接触;
Abstract: <正> 丙烯酰胺经皮接触的遗传毒性为探讨丙烯酰胺经皮肤接触对生殖细胞遗传基因的影响,作者采用经皮肤染毒方法进行小鼠显性致死试验,首次证明化学诱变物经皮接触能引起哺乳动物生殖细胞遗传性状改变。染毒组着床的胚胎死亡率明显高于对照组,发生一个或多个着床胚胎死亡的雌鼠比例明显超出对照组。除最低剂量组(25mg/kg/day)外,其它剂量组存活胚胎数明显减少。上述异常现象在柒毒后7~8天交配的动物比9~10天交配的动物明显。作者对存活胚胎平均数进行剂量一效应关系分析,存活
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