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Property of novel organic/inorganic amorphous calcium phosphate hybrid particles for loading and releasing 5-fluorouracil
Author(s): 
Pages: 66-71
Year: Issue:  1
Journal: Journal of Southwest University for Nationalities(Natrual Science Edition)

Keyword:  无定形磷酸钙药物载体5-氟尿嘧啶药物释放;
Abstract: 通过共沉淀法,在DNBP有机改性剂的存在下合成了纳米级别的无定形磷酸钙球形微粒(ACP),并以5-氟尿嘧啶(5-FU)为药物模型以ACP为载体在体外做了载药和药物释放研究,傅利叶红外衍射(FTIR),X-ray衍射(XRD),热重分析仪(TGA),扫描电镜(SEM),透射电镜(TEM),双光束紫外分光光度计(UV)对结果进行了一系列的表征,结果表明:有机/无机杂化无定形磷酸钙作为药物载体具有高载药率和较长的缓释效果,并在载药过程中会发生晶形的转变.
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