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Research progress on pharmacological mechanism of LMWH and its clinical indications
Author(s): 
Pages: 420-421,424
Year: Issue:  7
Journal: Qilu Pharmaceutical Affairs

Keyword:  Low - molecular - weight heparinAnticoagulationAntithrombosisIndication;
Abstract: Low - molecular - weight heparin(LMWH)is obtained by various methods of fractionation or depolymerisa-tion of polymeric heparin. Compare to unfractionated heparin(UFH),LMWH have relatively smaller molecular weight,better anti - Xa activity,greater bioavailability at low doses,longer half - life and more predictable anticoagulant response when administered in fixed doses. This article described the pharmacological mechanism of LMWH and their clinical indications.
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