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Serum level of IL-17A and TGF-β of patients with pneumoconiosis and their clinical significance
Author(s): 
Pages: 48-49,78
Year: Issue:  1
Journal: Occupational Health and Emergency Rescue

Keyword:  白介素-17A尘肺病TGF-βIL-17血清表达;
Abstract: [目的]检测白介素-17A(IL-17A)、TGF-β在壹、贰、叁期尘肺病患者血清中的水平,探讨其在壹、贰、叁期尘肺病发生和发展过程中的作用,为尘肺病发病机制的研究提供参考.[方法]随机抽取尘肺病患者,按照尘肺壹、贰、叁期分为三组,每组50例;设置正常对照组50人,采集四组患者血清,使用ELISA法检测各组患者血清中IL-17A、TGF-β水平.[结果]壹、贰、叁期尘肺病患者血清IL-17A、TGF-β表达水平高于正常对照组,差异有统计学意义(P<0.01);壹期患者血清IL-17A水平高于贰、叁期患者,差异有统计学意义(P<0.01);而TGF-β血清表达水平随期别增高而升高,组间差异有统计学意义(P<0.01).[结论]IL-17A、TGF-β在壹、贰、叁期尘肺病患者血清中存在高表达,早期检测TGF-β有助于了解疾病进展程度及严重程度.两者可能在尘肺早期及其发展过程中起到作用.
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