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Application of chemiluminescence microparticle immunoassay in detection of syphilis specific antibody
Author(s): 
Pages: 450-451
Year: Issue:  5
Journal: Occupational Health and Emergency Rescue

Keyword:  化学发光微粒子免疫梅毒特异性抗体甲苯胺红梅毒螺旋体明胶颗粒凝集TRUSTCMIATPPA;
Abstract: [目的]对化学发光微粒子免疫(chemiluminescence microparticle immuno assay,CMIA)法在梅毒特异性抗体检测中的应用价值进行分析,为今后的临床工作提供有价值的参考信息.[方法]选择2015年1月—2016年12月间收集到的需要进行梅毒筛查试验的3445份标本作为研究对象,对其分别采用CMIA法和梅毒甲苯胺红不加热血清试验(tolulized red unheated serum test,TRUST)法展开梅毒特异性抗体检测,并采用苍白密螺旋体明胶颗粒凝集试验(treponema pallidum particle assay,TPPA)对检测结果进行确认,对检测结果进行统计学分析.[结果]CMIA法测得阳性标本157份,阳性率4.56%;TRUST法测得阳性标本114份,阳性率为3.31%;前者阳性率高于后者,差异有统计学意义(P<0.05).CMIA法检测敏感性为99.36%,特异性为99.97%,假阳性率为0.03%,假阴性率为0.64%,正确指数为99.33%,诊断符合率为99.94%;TRUST法检测敏感性为67.52%,特异性为98.47%,假阳性率为0.24%,假阴性率为32.48%,正确指数为65.99%,诊断符合率为98.29%.前者检测敏感性、正确指数和诊断符合率高于后者,且假阳性率、假阴性率低于后者,差异均有统计学意义(P<0.01).[结论]在梅毒特异性抗体筛查中,CMIA法的准确性、敏感性均相对较高,临床价值显著,值得关注并推广.
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