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Application of Trihexyphenidyl in treatment of patients with acute severe organophosphate pesticides poisoning
Author(s): 
Pages: 441-442
Year: Issue:  5
Journal: Occupational Health and Emergency Rescue

Keyword:  苯海索重症有机磷农药中毒肌张力增高迟发性神经病呼吸衰竭住院时间;
Abstract: [目的]探讨苯海索对重症有机磷农药中毒并发肌张力增高患者的影响.[方法]选择重症有机磷农药中毒并发肌张力增高患者70例,随机分为治疗组(36例)和对照组(34例).对照组常规给予洗胃、特殊解毒药、对症及支持治疗.治疗组患者在对照组治疗的基础上,同时给予苯海索3次/d,每次2 mg,疗程3~31 d.[结果]治疗组患者呼吸衰竭发生率为19.5%,迟发性神经病发生率为5.6%,各低于对照组的70.6%、50.0%,差异均有统计学意义(P<0.01);治疗组死亡率为2.7%,低于对照组的14.7%,但差异无统计学意义(P>0.05).治疗组存活患者平均住院时间为(15.9±3.0)d,短于对照组存活患者的(27.3±3.6)d,差异有统计学意义(P<0.01).[结论]苯海索对重症有机磷农药中毒并发肌张力增高患者疗效较好,值得推广.
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