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Pages: 811-817
Year: Issue:  11
Journal: Chinese Journal of Pain Medicine

Keyword:  Gender differencePainRatParkinson' s disease6-OHDA;
Abstract: Objective:To compare the gender differences of 6-dopamine (6-hydroxydopamine, 6-OHDA) induced pain in rat model of Parkinson's disease (Parkinson' s disease, PD). The difference in time window of pain occurrence and pain duration between female and male rats were compared by behavioral tests.Methods:The adult Sprague-Dawley rats was divided into normal group, operation group and sham group. Each group included 12 rats (6 males and 6 females). PD model was established by Stereotaxic injection of 4 μl 6-OHDA into Substantia nigra pars reticulata (SNr). Paw withdrawal mechanical threshold and paw withdrawal thermal latency were tested in this study. Results:Stereotaxic injection of 6-OHDA successfully reproduced the PD model and caused pain behavior. There was no significant gender difference in male and female rats in normal group and sham group (mechanical allodynia :F = 1.103,P = 0.368 > 0.05; thermal hyperalgesia:F = 0.939,P = 0.510 > 0.05). The mechanical allodynia in the operation group: the female rats exhibited significant allodynia since 24 h after operation that continued to 56 d; the allodynia in male rats appeared in 7 d after operation, and recovered after 28 d. The thermal hyperalgesia in the operation group: the time window of hyperalgesia in the female and male rats was the same as that of mechanical allodynia. The female rats exhibited longer period of hyperalgesia than that of the male rats (female rats persisted 56 d; male rats persisted for 42 d).Conclusion: There are significant gender differences in mechanical allodynia and thermal hyperalgesia in male and female rats with 6-OHDA induced PD. Female animals seem to be more sensitive and more severin pain behavior in Parkinson' s disease.
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