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Diagnostic value of serum osteopontin for pneumoconiosis patients combined with heart failure
Author(s): 
Pages: 308-310,355
Year: Issue:  4
Journal: Occupational Health and Emergency Rescue

Keyword:  骨桥蛋白尘肺病心力衰竭血清;
Abstract: [目的]通过对尘肺病并发心力衰竭患者中骨桥蛋白(osteopontin,OPN)水平测定,分析OPN的临床意义.[方法]入选健康人群38人(对照组)、尘肺病患者25人(单纯尘肺病组)、尘肺病并发心力衰竭患者(尘肺病并发心力衰竭组)20人,分别测定三组血液生化指标和OPN水平,对结果进行统计学分析.[结果]尘肺病并发心力衰竭组血浆N末端B型利钠肽原(NT-proBNP)水平明显高于对照组及单纯尘肺病组,单纯尘肺病组、尘肺病并发心力衰竭组的WBC、超敏C反应蛋白(hs-CRP)高于对照组,差异均有统计学意义(P<0.01).对照组、单纯尘肺病组、尘肺病并发心力衰竭组中OPN水平分别为(71.3±15.3)ng/mL、(145.3±24.9)ng/mL、(199.4±25.2)ng/mL,尘肺病并发心力衰竭组高于对照组及尘肺病组(P<0.01).[结论]OPN可能参与了尘肺病并发心力衰竭的病理、生理过程,有望成为尘肺病并发心力衰竭早期血清学标志之一.
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