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wai zhou shen jing ya po xing sun shang yin qi sun shang qu zi fa fang dian de yan jiu gai shu
Author(s): 
Pages: 932-937
Year: Issue:  12
Journal: Chinese Journal of Pain Medicine

Keyword:  坐骨神经损伤自发放电节律离子通道;
Abstract: 坐骨神经慢性压迫损伤模型是神经病理性疼痛疾病动物模型的典型代表,其中损伤区产生节律丰富的自发放电和异位电活动,传入大脑皮层感觉中枢,是造成神经病理性疼痛的主要原因之一.因此研究神经损伤区自发放电的特点对于探索神经病理性疼痛的发生机理具有重要意义.本文基于坐骨神经慢性压迫损伤模型,从神经节律编码、损伤区丰富多样的放电节律以及节律间复杂的转迁模式几个方面对外周损伤区自发放电进行概述并对外周疼痛的治疗进行展望.
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