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AN EXPERIMENTAL STUDY OF PROFENOFOS ON LIPID PEROXIDATION IN ORGANIZATIONS OF RABBITS
Author(s): 
Pages: 115-116
Year: Issue:  3
Journal: OCCUPATIONAL HEALTH AND EMERGENCY RESCUE

Keyword:  丙溴磷组织脂质过氧化;
Abstract: 目的探讨丙溴磷对组织脂质过氧化的影响及意义.方法将家兔分为2个剂量组并经皮肤给予丙溴磷染毒,于染毒前和染毒后5d、10d,分别测定各组大脑、肝、肾组织中谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活力和维生素E(Vit E)浓度.结果染毒后家兔大脑、肝、肾组织中GSH-Px、SOD明显增高(P<0.05,P<0.01),Vit E浓度显著降低(P<0.05,P<0.01),并呈一定的剂量一效应关系.结论家兔大脑及肝组织脂质过氧化增强.可能是丙溴磷中毒导致其大脑、肝、肾功能受损的原因之一.
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